nitric oxide production-in-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T79981	Nitric oxide production-IN-1		NO Synthase
	Nitric oxide production-IN-1 (Compound 1) is an inhibitor of nitric oxide (NO) production extracted from Tupistra chinensis. It effectively suppresses NO synthesis in rat abdominal macrophages upon stimulation with lipop...		NO Synthase
TN6985	Anhydronotoptol	4-{[(2E,5E)-3,7-dimethylocta-2,5,7-trien-1-yl]oxy}-7H-furo[3,2-g]chromen-7-one	NO Synthase
	Anhydronotoptol (4-{[(2E,5E)-3,7-dimethylocta-2,5,7-trien-1-yl]oxy}-7H-furo[3,2-g]chromen-7-one), a natural compound extracted from the umbelliferae plant Qiangwu, is a potent inhibitor of nitric oxide production, inhibi...		NO Synthase
T5S2283	Sesamolin		p38 MAPK , Caspase , JNK
	1. Sesamolin and Sesamin has neuroprotective effect. 2. Sesamolin protects microglia against H2O2-induced cell injury, by inhibiting of p38 MAPK and caspase-3 activation and ROS production. 3. Sesamolin and Sesamin can s...		p38 MAPK , Caspase , JNK
T3S2259	Methyl eugenol	4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether	GABA Receptor
	1. Methyl eugenol (4-allylveratrole) is a natural constituent of the essential oils of a number of plants widely used in foodstuffs as flavouring agents, in view of the carcinogenic potential of ME, the need to check its...		GABA Receptor
T6S1665	Irisflorentin		Others , NO Synthase
	1. Irisflorentin blocks apoptosis pathways, by exerting its effects by promoting rpn-3 expression to enhance the activity of proteasomes and down-regulating egl-1 expression. 2. Irisflorentin has anti-inflammatory mechan...		Others , NO Synthase
T6S1487	Ginsenoside Rg5		NF-κB , COX , IGF-1R
	1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production and proinflammatory TNF-α secretion. 3. Ginsenoside Rg5 can ...		NF-κB , COX , IGF-1R
T61157	ABAI-30
	ABAI-30 is a highly potent and orally bioavailable anti-inflammatory compound that efficiently suppresses nitric oxide (NO) production in lipopolysaccharide (LPS) activated RAW264.7 cells [1].
TN4182	Hannokinol		Others
	(+)-Hannokinol and MESO-hannokinol can significantly inhibit lipopolysaccharide-induced nitric oxide production in BV2 microglial cells at concentrations ranging from 1 microM to 100 microM.		Others
T81684	Neuroinflammatory-IN-1
	Neuroinflammatory-IN-1 (Compound 5) serves as an anti-neuroinflammatory agent, exhibiting an inhibitory effect on nitric oxide (NO) production, with an IC50 of 65.4 μM [1].
T79955	Schiarisanrin A	Kadsulignan J	NO Synthase
	Schiarisanrin A (Kadsulignan J), a lignan, exhibits inhibitory activity on nitric oxide (NO) production, demonstrating an IC50 of 9.6 μM in BV-2 cells [1].		NO Synthase
T83049	Anti-inflammatory agent 63
	Anti-inflammatory agent 63 exhibits potent inhibitory activity (EC50 = 5.33±0.57 μM) against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells [1].
T81408	Preleoheterin
	Preleoheterin (Compound 3), a labdane diterpene isolated from L. japonicus [1], exhibits anti-inflammatory properties by inhibiting the production of nitric oxide and pro-inflammatory cytokines in LPS-activated macrophag...
T83553	(4S)-10-Nor-calamenen-10-one
	(4S)-10-Nor-calamenen-10-one (Compound 15), an eudesmane sesquiterpene sourced from Alpinia oxyphylla [1], amplifies LPS-induced nitric oxide (NO) production in microglial cells.
TMA1012	Ganoderiol F		Androgen Receptor , HIV Protease , Autophagy
	Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency virus-1 protease with IC(50) values of 20-40 microM. It induced...		Androgen Receptor , HIV Protease , Autophagy
T78229	Aminoguanidine hemisulfate		Reactive Oxygen Species
	Aminoguanidine hemisulfate, an inhibitor of nitric oxide synthases (NOS) and reactive oxygen species (ROS), effectively suppresses ANE-induced ROS production in vitro and is utilized in cancer research [1].		Reactive Oxygen Species
T83052	Anti-inflammatory agent 60		NF-κB
	Anti-inflammatory agent 60 (compound 21) inhibits nitric oxide production, presenting an IC50 of 12.95 μM, and reduces iNOS, phosphorylated p65, and β-catenin expression in a concentration-dependent manner [1].		NF-κB
T81987	Kanzonol D
	Kanzonol D, a flavonoid derived from the hairy root cultures of Glycyrrhiza glabra [1], exhibits anti-inflammatory and anticancer properties by inhibiting nitric oxide production and suppressing NF-κB activation. It also...
T79930	Sanggenon A	Sanggenone A	NF-κB
	Sanggenon A (Sanggenone A) exhibits anti-inflammatory properties by modulating the NF-κB and HO-1/Nrf2 signaling pathways in BV2 and RAW264.7 cells, and it significantly suppresses Lipopolysaccharide (LPS)-induced nitric...		NF-κB
T79954	Kadsulignan H		NO Synthase
	Kadsulignan H (compound 13), a lignan, exhibits inhibitory activity on nitric oxide (NO) production, presenting an IC50 value of 14.1 μM in BV-2 cells [1].		NO Synthase
T61821	COX-2-IN-16
	COX-2-IN-16 (compound 2b) is a potent, selective, and orally active inhibitor of cyclooxygenase-2 (COX-2) with an IC50 value of 102 μM. It effectively reduces nitric oxide (NO) production and demonstrates anti-inflammato...